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IV Ozone Therapy: Benefits and How It Works

March 13, 2025

Dr. Karen Plymel


IV Ozone Therapy: Benefits and How It Works
In recent years, IV ozone therapy has gained attention for its potential health benefits, particularly in the realm of alternative and integrative medicine. This innovative therapy involves introducing ozone—a highly reactive form of oxygen—into the bloodstream to promote healing, boost immunity, and improve overall well-being. But how does IV ozone therapy work, and what are its benefits? Let’s explore.

What Is IV Ozone Therapy?
Ozone (O₃) is a naturally occurring gas composed of three oxygen atoms. While ozone is most associated with the Earth's atmosphere, it has been used therapeutically for decades due to its powerful antimicrobial and immune-boosting properties.
IV ozone therapy involves drawing a patient’s blood, mixing it with medical-grade ozone, and reinfusing it into the body. This process, known as major auto-hemotherapy (MAH), allows ozone to interact with the blood, enhancing oxygen utilization and stimulating the body's natural healing processes.

How IV Ozone Therapy Works

1. Blood Extraction – A small amount of blood is drawn from the patient, typically around 50-250 ml, depending on the treatment protocol.

2. Ozone Infusion – The extracted blood is mixed with medical-grade ozone, which reacts with the blood components to form ozonide’s and peroxides. These molecules help stimulate biological processes.

3. Reinfusion – The ozonated blood is then reintroduced into the patient’s bloodstream, allowing the body to absorb and utilize the ozone-enhanced compounds.

This therapy is believed to improve oxygen efficiency, modulate the immune system, and help the body combat infections, inflammation, and oxidative stress.

Benefits of IV Ozone Therapy

1. Boosts Immune Function
Ozone therapy stimulates the immune system by increasing cytokine production. This can help the body fight off infections, viruses, and chronic diseases.

2. Improves Oxygen Utilization
By enhancing oxygen metabolism at the cellular level, IV ozone therapy supports better circulation and overall oxygen delivery to tissues, which is beneficial for people with chronic fatigue, fibromyalgia, and cardiovascular issues.

3. Reduces Inflammation
Chronic inflammation is linked to various diseases, including arthritis, autoimmune disorders, and neurodegenerative conditions. Ozone therapy helps regulate inflammatory responses and may provide relief for inflammatory conditions.

4. Fights Bacteria, Viruses, and Fungi
Ozone has strong antimicrobial properties, making it effective against infections caused by bacteria, viruses, and fungi. Some studies suggest it may help with conditions like Lyme disease, chronic viral infections, and mold toxicity.

5. Supports Detoxification
By stimulating the liver and lymphatic system, ozone therapy can help remove toxins from the body, which is particularly beneficial for individuals exposed to heavy metals or environmental pollutants.

6. Enhances Energy and Mitochondrial Function
Mitochondria, the powerhouses of our cells, play a crucial role in energy production. Ozone therapy helps optimize mitochondrial function, leading to increased energy and reduced fatigue.

7. Aids in Wound Healing and Tissue Regeneration
Ozone therapy has been used in wound healing, particularly for diabetic ulcers and non-healing infections. Its ability to promote circulation and cellular repair makes it valuable in regenerative medicine.

Is IV Ozone Therapy Safe?
When administered by trained professionals, IV ozone therapy is considered safe. However, some individuals may experience mild side effects, such as dizziness, fatigue, or flu-like symptoms, as the body detoxifies. It’s essential to consult with a qualified healthcare provider before starting ozone therapy, especially for individuals with underlying health conditions.

Final Thoughts
IV ozone therapy offers a promising approach to health optimization, with potential benefits ranging from immune support and reduced inflammation to increased energy and detoxification. While more research is needed to fully understand its long-term effects, many individuals report significant improvements in their overall well-being after undergoing treatment.

If you’re considering IV ozone therapy, consult with a knowledgeable healthcare provider to determine whether it’s right for you. As interest in holistic and integrative medicine grows, ozone therapy continues to be a fascinating and evolving field in modern healthcare.


By Dr. Karen Plymel February 8, 2025
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By Karen Plymel, MD January 17, 2025
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