Blog Layout

Medical Weight Loss: A Comprehensive Guide to Ozempic, Wegovy, and Other GLP-1 Options

November 12, 2024

Dr. Karen Plymel

GLP-1 Agonists for Medical Weight Loss: Safety, Efficacy, and Cost Considerations

Image of a woman using a tape measure to measure her midsection

In the ever-evolving landscape of weight loss treatments, GLP-1 agonists have garnered attention for their potential to help individuals manage obesity and related conditions. With increasing global obesity rates, finding effective weight management solutions has never been more critical. This article delves into the role of GLP-1 agonists in medical weight loss, their safety, efficacy, and cost considerations, as well as comparisons with other weight loss options.

What Are GLP-1 Agonists?

GLP-1 agonists, such as Ozempic and Wegovy, mimic the action of glucagon-like peptide-1 (GLP-1), a hormone naturally produced by the body. GLP-1 regulates appetite, glucose metabolism, and insulin secretion. By targeting GLP-1 receptors in the brain and pancreas, these medications effectively reduce appetite, increase satiety, and improve insulin sensitivity, which can contribute to significant weight loss.

Efficacy of GLP-1 Agonists for Weight Loss

GLP-1 agonists have demonstrated substantial efficacy in clinical trials for weight loss. By stimulating GLP-1 receptors in the brain, these medications reduce appetite and help individuals feel full with less food intake. They also slow gastric emptying, which further contributes to weight loss. In addition to weight reduction, GLP-1 agonists improve glycemic control in people with type 2 diabetes, making them a powerful tool for managing both weight and metabolic health.

Safety Considerations and Side Effects

GLP-1 agonists are generally well-tolerated, with common side effects including nausea, vomiting, and diarrhea, especially during the initial stages of treatment. While severe side effects, such as pancreatitis or thyroid cancer, are rare, it's important to consult with a healthcare provider before starting treatment, particularly for those with a history of these conditions. Long-term safety data is still under review, but current research suggests that the benefits of GLP-1 agonists often outweigh the risks for most patients.

Cost and Accessibility: Branded vs. Compounded Options

While branded GLP-1 agonists like Ozempic and Wegovy are effective, they can be costly. Compounded semaglutide, a more affordable option prepared by compounding pharmacies, offers a customizable alternative. This allows patients to potentially lower costs and tailor the formulation to their needs, though it's important to consult a healthcare provider before opting for compounded versions.

Other Medical Weight Loss Solutions

While GLP-1 agonists show promise, they are not the only weight loss medications available. Other options include:

  • Contrave: A combination of bupropion and naltrexone that reduces appetite and cravings while increasing energy expenditure.
  • Phentermine: A stimulant that suppresses appetite, typically used short-term in combination with lifestyle changes.
  • Alli: An over-the-counter medication that inhibits fat absorption, helping individuals reduce calorie intake from fat-containing foods.
  • Saxenda: A GLP-1 receptor agonist approved specifically for weight loss, functioning similarly to Ozempic and Wegovy but with an explicit focus on reducing food intake.

Comparing GLP-1 Agonists with Other Weight Loss Medications

GLP-1 agonists have the advantage of targeting both appetite regulation and glucose metabolism, making them especially effective for individuals with obesity and type 2 diabetes. However, individual responses to different medications can vary, so it’s essential to collaborate with healthcare providers to find the best treatment approach based on personal needs and medical history.


While GLP-1 agonists offer a promising avenue for weight loss, it's essential to explore other medical weight loss solutions to provide a comprehensive approach to managing obesity and related conditions. Here's an overview of some alternative options:


Contrave

Contrave is a combination medication containing bupropion and naltrexone. It works by reducing appetite and cravings while increasing energy expenditure, making it an effective option for individuals struggling with overeating and food addiction.


Phentermine

Phentermine is a stimulant medication that suppresses appetite by acting on the central nervous system. It is typically used as a short-term adjunct to lifestyle modifications for weight loss in individuals with obesity.


Alli

Alli is an over-the-counter medication containing orlistat, a lipase inhibitor that prevents the absorption of dietary fats. It can help individuals lose weight by reducing the number of calories absorbed from fat-containing foods.


Saxenda

Saxenda is a GLP-1 receptor agonist similar to Ozempic and Wegovy but is specifically approved for weight loss in individuals with obesity. It works by regulating appetite and slowing gastric emptying, leading to reduced food intake and weight loss.


Comparing Other Medical Weight Loss Options with GLP-1 Agonist Treatments


  • While these medications offer various mechanisms of action for weight loss, GLP-1 agonists like Ozempic and Wegovy have the advantage of directly targeting appetite regulation and glucose metabolism, making them highly effective options for individuals with obesity and type 2 diabetes.


  • However, individual responses to different weight loss medications can vary, and it's essential to work closely with healthcare providers to determine the most suitable treatment approach based on individual needs and medical history.


GLP-1 agonists are a class of medications designed to mimic the action of glucagon-like peptide-1 (GLP-1), a hormone naturally produced in the body. GLP-1 plays a crucial role in regulating appetite, glucose metabolism, and insulin secretion. By targeting GLP-1 receptors in the brain and pancreas, GLP-1 agonists exert their effects on weight loss and glycemic control.


Overview of GLP-1 Agonists:


  • GLP-1 agonists work by stimulating GLP-1 receptors in the brain, leading to decreased appetite and increased feelings of fullness.


  • In addition to their effects on appetite, GLP-1 agonists also slow down gastric emptying, which can further contribute to weight loss.


  • These medications have been shown to improve glycemic control in individuals with type 2 diabetes, making them a valuable option for those with obesity-related metabolic disorders.


Comparison of Branded Options and Compounded Semaglutide


  • Ozempic and Wegovy are branded GLP-1 agonists. These two branded agents are made by the same manufacturer and are essentially the same medication, with semaglutide as the active ingredient. Ozempic is indicated for glycemic control and cardiovascular risk reduction in patients with type II diabetes, while Wegovy is indicated for weight loss.


  • Compounded semaglutide formulations offer a customizable alternative prepared by compounding pharmacies. This may provide a more cost-effective option for some individuals compared to branded options, as well as the option to customize formulations to include other peptides that may enhance the anti-inflammatory response.


  • Additionally, tirzepetide (branded Mounjaro/Zepbound) is an emerging GLP-1 agonist with a dual mechanism of action that targets both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual action allows it to not only help with weight loss by suppressing appetite but also to assist in managing blood sugar levels, providing a broader approach to weight management​.​​ Just as Ozempic and Wegovy are essentially the same drug, Mounjaro and Zepbound have tirzepetide as the active ingredient in both agents, but with different indications.


  • Ozempic/Wegovy, Mounjaro/Zepbound and compounded versions of both are given as once weekly injections.


Efficacy and Safety


  • Clinical trials have demonstrated the efficacy of GLP-1 agonists in promoting weight loss and improving metabolic parameters.


  • These medications are generally well-tolerated, with common side effects including nausea, vomiting, and diarrhea. However, severe adverse events can occur but are rare.


  • Long-term safety data are still being studied, but current evidence suggests that GLP-1 agonists offer a favorable risk-benefit profile for most individuals.


  • Before starting either medication, it's vital to discuss with your healthcare provider any potential risks, especially if you have a history of thyroid cancer, pancreatitis, or are pregnant or planning to become pregnant.


  • All of these medications have interactions with other drugs, so providing a complete list of your current medications to your physician is essential​.


Conclusion

GLP-1 agonists are a promising solution for weight loss, offering effective appetite suppression, improved glycemic control, and long-term weight management. With options like Ozempic, Wegovy, and compounded formulations, GLP-1 agonists provide flexibility and convenience for individuals seeking help with obesity and metabolic conditions. As with any medical treatment, it's important to consult with a healthcare provider to discuss risks, benefits, and the most suitable treatment for your specific needs.


In summary, GLP-1 agonists represent a promising option for medical weight loss, offering significant benefits in terms of appetite suppression, glycemic control, and weight reduction. Whether through branded options like Ozempic and Wegovy or compounded formulatio ns, GLP-1 agonists have the potential to make a meaningful impact on the lives of individuals struggling with obesity and related metabolic disorders.


IV ozone therapy session in a clinical setting, Ozone therapy benefits infographic

IV Ozone Therapy: Benefits and How It Works

By Dr. Karen Plymel • March 13, 2025
Discover the powerful benefits of IV ozone therapy, including immune support, improved oxygen utilization, and reduced inflammation. Learn how this innovative treatment works and why it's gaining popularity in holistic medicine.

Is Your Black Plastic Spatula Leaking Toxins Into Your Food?

By Dr. Karen Plymel • February 8, 2025
The Hidden Dangers of Black Plastic in Your Kitchen Black plastic kitchenware is a common sight in many homes, found in everything from spatulas and tongs to food storage containers. But while these tools may be convenient, they could also be leaching harmful chemicals into your food—especially when exposed to heat. How Black Plastic Puts Your Health at Risk Many black plastic utensils contain flame retardants and other toxic chemicals, which can transfer into your food when used at high temperatures. Stirring a hot pot, scraping the bottom of a pan, or leaving a spatula on a hot stove can all increase the risk of exposure. Research has linked these chemicals to thyroid disease, diabetes, cancer, and reproductive, neurological, and immune system damage. Where Do These Chemicals Come From? A key concern is that some black plastic kitchenware is made from recycled electronics , which can contain flame retardants and other hazardous substances. A 2018 study found that these chemicals can easily transfer into cooking oil, significantly increasing health risks. More recently, a 2024 study revealed that kitchen utensils contain some of the highest levels of flame retardants among tested consumer products. But it’s not just cooking utensils. Black plastic is also used in takeout containers, food trays, and even coffee cup lids , all of which can contribute to chemical and microplastic exposure. Microplastics: An Invisible Threat Beyond chemical exposure, black plastic can also release microplastics—tiny plastic particles that can enter the body through food and beverages. These microscopic particles have been linked to gut health issues, kidney damage, and other long-term health risks. Even if black plastic containers aren’t heated directly, hot food and drinks can still cause chemical and microplastic leaching. Sushi trays, takeout boxes, and plastic lids may all contribute to unintended exposure. How to Reduce Your Risk While completely avoiding plastic might not be realistic, here are some simple steps to limit your exposure to harmful chemicals: ✅ Use wood or metal utensils instead of black plastic for cooking. ✅ Choose glass, stainless steel, or ceramic for food storage. ✅ Cook at home more often to reduce the use of takeout containers. ✅ Drink from a reusable mug instead of using plastic cup lids. The Need for Safer Solutions Despite growing concerns, many black plastic products lack clear labeling about their chemical content. Stronger safety regulations and more transparency in plastic recycling are crucial for protecting consumers from unknown risks. In the meantime, making small changes in your kitchen can help reduce your exposure and protect your health . Have you switched to safer alternatives? Share your thoughts in the comments!

Embracing Healthy Eating: The Power of Balance and Flexibility

By Karen Plymel, MD • January 17, 2025
In the pursuit of a healthier lifestyle, the concept of dietary adherence plays a pivotal role. Many individuals embark on diets with the intention of losing weight or improving their overall health, yet they often encounter challenges that lead to frustration and abandonment of their goals. One of the most significant pitfalls is the tendency to completely cut out favorite foods. However, research suggests that a more flexible approach to dieting can yield better long-term results. The Importance of Dietary Adherence Dietary adherence refers to the extent to which individuals stick to their dietary plans. Studies indicate that the more flexible a diet is, the more likely individuals are to maintain it over time. This flexibility allows for the inclusion of a variety of foods, which can prevent feelings of deprivation. For instance, a study found that participants who included bread in their diets experienced fewer dropouts compared to those who eliminated it entirely. This highlights the importance of allowing for personal preferences within a dietary framework. Flexible Dieting: A Sustainable Approach Flexible dieting is an approach that encourages individuals to enjoy their favorite foods in moderation rather than eliminating them altogether. This method not only fosters a healthier relationship with food but also promotes better adherence to dietary plans. Instead of viewing foods like Oreos, candies, or chocolate as forbidden, individuals can learn to enjoy these treats occasionally while focusing on incorporating more nutritious options into their meals. For example, rather than completely cutting out sweets, one might choose to limit their consumption to special occasions or designate a specific day for indulgence. This strategy can help mitigate cravings and reduce the likelihood of binge eating, which often occurs when people feel deprived. Positive Dietary Changes In addition to allowing for occasional indulgences, making positive dietary changes is crucial for long-term success. This involves focusing on adding healthier foods to one’s diet rather than solely concentrating on what to eliminate. Increasing the intake of vegetables, fruits, whole grains, and lean proteins can significantly enhance overall nutrition. For instance, incorporating a variety of colorful vegetables into meals not only boosts nutrient intake but also adds flavor and visual appeal. Similarly, opting for lean protein sources, such as chicken, fish, or legumes, can help maintain satiety and support muscle health. The Balanced Approach A balanced approach to eating is essential for sustainable dietary adherence. This means including favorite foods in moderation while prioritizing healthier choices. By adopting this mindset, individuals can create a more enjoyable and less restrictive eating plan. For example, someone who loves pizza can enjoy a slice while pairing it with a side salad loaded with vegetables. This not only satisfies cravings but also ensures that the meal is nutritionally balanced. The key is to find harmony between indulgence and health, allowing for enjoyment without compromising overall well-being. The Key to Success In summary, the journey toward healthy eating does not have to be a rigid or punitive experience. The key to a successful diet lies in balance and flexibility. Completely cutting out favorite foods can lead to feelings of deprivation, ultimately resulting in failure to adhere to dietary goals. Instead, focusing on moderation and incorporating healthier options can create a sustainable and enjoyable eating plan. By embracing a flexible approach to dieting, individuals can foster a positive relationship with food, enhance their dietary adherence, and achieve long-term health benefits. Remember, healthy eating is not about perfection; it’s about making informed choices that align with personal preferences and lifestyle. So, indulge occasionally, savor your favorite treats, and prioritize nutritious foods to cultivate a balanced and fulfilling diet.

Why Zinc Oxide Sunscreens Provide Superior Sun Protection

By Karen Plymel,MD • June 17, 2024
Sunscreen is a vital part of any skincare regimen, especially for those concerned with preventing sun damage, photoaging, and skin cancer. With UV radiation being a major contributor to these issues, it's crucial to understand the two primary categories of sunscreen: chemical (organic) and physical (mineral) sunscreens. This article focuses on zinc oxide, a key ingredient in physical sunscreens, and compares its benefits to chemical UV filters and titanium dioxide. The Power of Zinc Oxide Zinc oxide, a mineral-based sunscreen agent, provides broad-spectrum protection against both UVB and UVA rays. Its physical mechanism reflects UV rays, unlike chemical filters that absorb and convert UV radiation into heat. Zinc oxide's non-penetrative nature reduces irritation and the risk of systemic absorption, making it an ideal choice for sensitive skin. Zinc Oxide vs. Chemical Filters While chemical sunscreens use organic compounds to absorb UV radiation, zinc oxide reflects and scatters it, offering superior protection. Zinc oxide also has the advantage of photostability, meaning it remains effective longer compared to some chemical filters that degrade under sun exposure. Furthermore, zinc oxide provides broader protection against UVA rays, including the long-wave UVA that contributes to skin aging and cancer. Why Choose Zinc Oxide? Broad-Spectrum Protection : Blocks both UVA and UVB rays. Stability : Does not break down easily under sun exposure, offering lasting protection. Skin-Friendly : Ideal for all skin types, especially sensitive or acne-prone skin. Eco-Friendly : Zinc oxide is reef-safe, unlike many chemical sunscreens linked to coral bleaching.  Final Recommendations Zinc oxide is the best choice for sun protection. Its broad-spectrum efficacy, stability, skin compatibility, and environmental benefits make it superior to chemical filters and titanium dioxide. I strongly recommend incorporating a high-quality, broad-spectrum zinc oxide sunscreen into your daily skincare routine to protect your skin from harmful UV radiation and to ensure healthier skin over time.
Female physician checking female patient's blood pressure

Decoding Holistic Healthcare: Functional, Alternative and Naturopathic Medicine

February 5, 2024
Explore the differences between conventional medicine, functional medicine, alternative therapies, and naturopathic care to make informed decisions about your healthcare journey. Understand the unique philosophies, practitioners, and treatment modalities to find the best approach for your well-being.
Share by: